relevant spatial scales of chemical variation in aplysina aerophoba相关的空间尺度上的化学变化aplysina aerophoba.pdfVIP

Mar. Drugs 2011, 9, 2499-2513; doi:10.3390/md9122499 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Relevant Spatial Scales of Chemical Variation in Aplysina aerophoba Oriol Sacristan-Soriano 1, Bernard Banaigs 2 and Mikel A. Becerro 3,* 1 Center for Advanced Studies of Blanes (CEAB-CSIC), Accés a la Cala St. Francesc 14, Blanes 17300, Girona, Spain; E-Mail: osacristan@ceab.csic.es 2 Environmental and Biomolecular Chemistry Laboratory, University of Perpignan Via Domitia, 52 Paul Alduy Ave., Perpignan Cedex 66860, France; E-Mail: banaigs@univ-perp.fr 3 Natural Products and Agrobiology Institute (IPNA-CSIC), Avda. Astrofísico Francisco Sánchez 3, La Laguna, Tenerife 38206, Spain * Author to whom correspondence should be addressed; E-Mail: m.becerro@csic.es; Tel.: +34-922-256-847; Fax: +34-922-260-135. Received: 11 October 2011; in revised form: 14 November 2011 / Accepted: 16 November 2011 / Published: 28 November 2011 Abstract: Understanding the scale at which natural products vary the most is critical because it sheds light on the type of factors that regulate their production. The sponge Aplysina aerophoba is a common Mediterranean sponge inhabiting shallow waters in the Mediterranean and its area of influence in Atlantic Ocean. This species contains large concentrations of brominated alkaloids (BAs) that play a number of ecological roles in nature. Our research investigates the ecological variation