原创力文档relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage相对比例和纬向分布的人类骨关节炎的间叶细胞祖细胞和正常软骨.pdfVIP
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relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage相对比例和纬向分布的人类骨关节炎的间叶细胞祖细胞和正常软骨
Pretzel et al. Arthritis Research Therapy 2011, 13:R64
/content/13/2/R64
RESEARCH ARTICLE Open Access
Relative percentage and zonal distribution of
mesenchymal progenitor cells in human
osteoarthritic and normal cartilage
1,2* 1 1 3 3 4
David Pretzel , Stefanie Linss , Steffen Rochler , Michaela Endres , Christian Kaps , Saifeddin Alsalameh and
Raimund W Kinne1
Abstract
Introduction: Mesenchymal stem cells (MSC) are highly attractive for use in cartilage regeneration. To date, MSC
are usually recruited from subchondral bone marrow using microfracture. Recent data suggest that isolated cells
from adult human articular cartilage, which express the combination of the cell-surface markers CD105 and CD166,
are multi-potent mesenchymal progenitor cells (MPC) with characteristics similar to MSC. MPC within the cartilage
matrix, the target of tissue regeneration, may provide the basis for in situ regeneration of focal cartilage defects.
However, there is only limited information concerning the presence/abundance of CD105+/CD166+ MPC in human
articular cartilage. The present study therefore assessed the relative percentage and particularly the zonal
distribution of cartilage MPC using the markers CD105/CD166.
Methods: Specimens of human osteoarthritic (OA; n = 11) and normal (n = 3) cartilage were used for either cell
isolation or immunohistochemistry. Due to low numbers, isolated cells were expanded for 2 weeks and then
analyzed by flow cytometry (FACS) or immunofluorescence in chamber slides for the expression of CD105 and
+ -
CD166. Following immunomagnetic separation of CD166 / OA
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