response properties of human amygdala subregions evidence based on functional mri combined with probabilistic anatomical maps响应性质的人类杏仁核条件证据基于功能磁共振成像结合概率解剖地图.pdfVIP

Response Properties of Human Amygdala Subregions: Evidence Based on Functional MRI Combined with Probabilistic Anatomical Maps Tonio Ball1,2,3,4.*, Benjamin Rahm3,5,6, Simon B. Eickhoff7,8, Andreas Schulze-Bonhage1,3,4, Oliver Speck3,9, Isabella Mutschler1,2,3. 1 Epilepsy Center, University Hospital Freiburg, Freiburg, Germany, 2 Heidelberg Academy of Science and Humanities, Heidelberg, Germany, 3 Freiburg Brain Imaging, University Hospital Freiburg, Freiburg, Germany, 4 Bernstein Center for Computational Neuroscience Freiburg, Freiburg, Germany, 5 Departement of Cognitive Psychology and Methodology, University of Basel, Basel, Switzerland, 6 Institute of Medical Psychology, ¨ ¨ University of Frankfurt, Frankfurt, Germany, 7 Institute for Medicine, Research Center Julich, Julich, Germany, 8 CO Institute for Brain Research, ¨ ¨ University of Dusseldorf, Dusseldorf, Germany, 9 Departement of Biomedical Magnetic Resonance, Institute for Experimental Physics, University of Magdeburg, Magdeburg, Germany The human amygdala is thought to play a pivotal role in the processing of emotionally significant sensory information. The major subdivisions of the human amygdala—the laterobasal group (LB), the superficial group (SF), and the centromedial group (CM)—have been anatomically delineated, but the functional response properties of these amygdala subregions in humans are still unclear. We combined functional MRI with cyto-architectonically defined probabilistic maps to analyze the response characteristics of amygdala subregions in subjects presented with auditory stimuli. We found positive auditory stimulation- related signal changes predominantly in probabilistically defined LB, and negative responses predominantly in SF and CM. In the left amygdala, mean res