原创力文档risk and protective genetic variants in suicidal behaviour association with slc1a2, slc1a3, 5-htr1b ntrk2 polymorphisms风险和保护的遗传变异与slc1a2自杀行为协会,slc1a3 5-htr1b ntrk2多态性.pdfVIP
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riskandprotectivegeneticvariantsinsuicidalbehaviourassociationwithslc1a2,slc1a3,5-htr1b
Murphy et al. Behavioral and Brain Functions 2011, 7:22
/content/7/1/22
RESEARCH Open Access
Risk and protective genetic variants in suicidal
behaviour: association with SLC1A2, SLC1A3,
5-HTR1B NTRK2 polymorphisms
1* 1 2 3 3 3 4
Therese M Murphy , Maria Ryan , Tom Foster , Chris Kelly , Roy McClelland , John O’Grady , Eleanor Corcoran ,
4 5 6 7 7 8 2
John Brady , Michael Reilly , Anne Jeffers , Katherine Brown , Anne Maher , Noreen Bannan , Alison Casement ,
2 1 9 10 1 11,12 12
Dermot Lynch , Sharon Bolger , Prerna Tewari , Avril Buckley , Leah Quinlivan , Leslie Daly , Cecily Kelleher
and Kevin M Malone1
Abstract
Background: Suicidal behaviour is known to aggregate in families. Patients with psychiatric disorders are at higher
risk for suicide attempts (SA), however protective and risk genetic variants for suicide appear to be independent of
underlying psychiatric disorders. Here we investigate genetic variants in genes important for neurobiological
pathways linked to suicidal behaviour and/or associated endophenotypes, for association with SA among patients
with co-existing psychiatric illness. Selected gene-gene and gene-environment interactions were also tested.
Methods: DNA was obtained from bloods of 159 patients (76 suicide attempters and 83 non-attempters), who
were profiled for DSM-IV Axis I psychiatric diagnosis. Twenty-eight single nucleotide polymorphisms (SNPs) from 18
candidate genes (COMT, 5-HT2A, 5-HT1A, 5-HT
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