risk assessment of clinical reactions to legumes in peanut-allergic children风险评估的临床反应豆类花生过敏的孩子.pdfVIP
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risk assessment of clinical reactions to legumes in peanut-allergic children风险评估的临床反应豆类花生过敏的孩子
ORIGINAL ARTICLE
Risk Assessment of Clinical Reactions to Legumes
in Peanut-Allergic Children
Louise Bjerremann Jensen,*|| Milene Andersen,þ Per Stahl Skov,||§
Lars K. Poulsen,|| and Carsten Bindslev-Jensenþ
their caretakers benefit from a realistic knowledge of their
Abstract: Peanut-allergic children might be at risk for reactions to
personal threshold.
other legumes. However, it is not always possible to perform multiple
Cross-reactivity is observed when preexisting immuno-
oral food challenges in children. On the basis of patient case history,
globulin E (IgE) antibodies recognize similar epitopes on other
in vitro diagnostic tests, and eventually food challenges, we aimed at 4
proteins than the protein they were originally sensitized to,
developing an algorithm for risk assessment of possible clinical re-
and several studies on legume cross-reactivity have been
actions to other legumes (soybean, lupine, fresh, and blanched green 5
published. Magni et al investigated the degree of in vitro
pea). Seventy-five consecutive pati
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