risk of severe knee and hip osteoarthritis in relation to level of physical exercise a prospective cohort study of long-distance skiers in sweden严重的膝盖和髋关节骨关节炎的风险与身体锻炼水平长途滑雪者在瑞典的前瞻性队列研究.pdfVIP

Risk of Severe Knee and Hip Osteoarthritis in Relation to Level of Physical Exercise: A Prospective Cohort Study of Long-Distance Skiers in Sweden ¨ 1,2 1,2 3 ˚ 2,4 3 Karl Michaelsson *, Liisa Byberg , Anders Ahlbom , Hakan Melhus , Bahman Y. Farahmand 1 Department of Surgical Sciences, Section of Orthopaedics, Uppsala University, Uppsala, Sweden, 2 Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden, 3 The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 4 Department of Medical Sciences, Section of Clinical Pharmacology, Uppsala University, Uppsala, Sweden Abstract Background: To complete long-distance ski races, regular physical exercise is required. This includes not only cross-country skiing but also endurance exercise during the snow-free seasons. The aim of this study was to determine whether the level of physical exercise is associated with future risk of severe osteoarthritis independent of previous diseases and injuries. Methodology/Principal Findings: We used a cohort that consisted of 48 574 men and 5 409 women who participated in the 90 km ski race Vasaloppet at least once between 1989 and 1998. Number of performed races and finishing time were used as estimates of exercise level. By matching to the National Patient Register we identified participants with severe osteoarthritis, defined as arthroplasty of knee or hip due to osteoarthritis. With an average follow-up of 10 years, we identified 528 men and 42 women with incident osteoarthritis. The crude rate was 1.1/1000 person-years for men and 0.8/ 1000 person-years for women. Compared with racing once, participation in $5 races w