role of fibroblast growth factor 8 (fgf8) in animal models of osteoarthritis纤维母细胞生长因子的作用8(fgf8)在骨关节炎动物模型.pdfVIP

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role of fibroblast growth factor 8 (fgf8) in animal models of osteoarthritis纤维母细胞生长因子的作用8(fgf8)在骨关节炎动物模型.pdf

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role of fibroblast growth factor 8 (fgf8) in animal models of osteoarthritis纤维母细胞生长因子的作用8(fgf8)在骨关节炎动物模型

Available online /content/10/4/R90 Vol 10 No 4 Open Access Research article Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis 1 1 1 1,2 3 Masako Uchii , Tadafumi Tamura , Toshio Suda , Masakazu Kakuni , Akira Tanaka and Ichiro Miki1 1Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd, 1188 Shimotogari, Nagaizumi, Sunto, Shizuoka 411-8731, Japan 2Present address: PhoenixBio Co., Ltd, 3-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan 3Department of Pathology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Corresponding author: Ichiro Miki, ichiro.miki@kyowa.co.jp Received: 13 May 2008 Revisions requested: 26 Jun 2008 Revisions received: 22 Jul 2008 Accepted: 12 Aug 2008 Published: 12 Aug 2008 Arthritis Research Therapy 2008, 10:R90 (doi:10.1186/ar2474) This article is online at: /content/10/4/R90 © 2008 Uchii et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Fibroblast growth factor 8 (FGF8) is isolated as an Results The expression of FGF8 in hyperplastic synovial cells androgen-induced growth factor, and has recently been shown and fibroblasts was induced in the meniscectomized OA model, to contribute to limb morphogenesis. The aim of the present whereas little