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role of inflammation and oxidative stress mediators in gliomas炎症和氧化应激的作用在神经胶质瘤介质.pdf

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role of inflammation and oxidative stress mediators in gliomas炎症和氧化应激的作用在神经胶质瘤介质

Cancers 2010, 2, 693-712; doi:10.3390/cancers2020693 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Role of Inflammation and Oxidative Stress Mediators in Gliomas Alfredo Conti *, Carlo Gulì, Domenico La Torre, Chiara Tomasello, Filippo F. Angileri and M’Hammed Aguennouz Department of Neuroscience and Department of Oncology, University of Messina, Policlinico Universitario, Via Consolare Valeria 1, 98125, Messina, Italy * Author to whom correspondence should be addressed; E-Mail: alfredo.conti@unime.it; Tel.: +39-090-2212862; Fax: +39-090-693714. Received: 20 February 2010; in revised form: 20 April 2010 / Accepted: 21 April 2010 / Published: 26 April 2010 Abstract: Gliomas are the most common primary brain tumors of the central nervous system. Despite relevant progress in conventional treatments, the prognosis of such tumors remains almost invariably dismal. The genesis of gliomas is a complex, multistep process that includes cellular neoplastic transformation, resistance to apoptosis, loss of control of the cell cycle, angiogenesis, and the acquisition of invasive properties. Among a number of different biomolecular events, the existence of molecular connections between inflammation and oxidative stress pathways and the development of this cancer has been demonstrated. In particular, the tumor microenvironment, which is largely orchestrated by inflammatory molecules, is an indispensable participant in the neoplastic process,