原创力文档role of vascular endothelial growth factor (vegf) and vegf-r genotyping in guiding the metastatic process in pt4a resected gastric cancer patients血管内皮生长因子(vegf)的作用和基因分型结果vegf-r指导pt4a切除胃癌患者的转移过程.pdfVIP
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role of vascular endothelial growth factor (vegf) and vegf-r genotyping in guiding the metastatic process in pt4a resected gastric cancer patients血管内皮生长因子(vegf)的作用和基因分型结果vegf-r指导pt4a切除胃癌患者的转移过程
Role of Vascular Endothelial Growth Factor (VEGF) and
VEGF-R Genotyping in Guiding the Metastatic Process in
pT4a Resected Gastric Cancer Patients
1 2 3 4 5
Mario Scartozzi *, Cristian Loretelli , Eva Galizia , Alessandra Mandolesi , Mirco Pistelli ,
5 1 5 5 5
Alessandro Bittoni , Riccardo Giampieri , Luca Faloppi , Maristella Bianconi , Michela Del Prete ,
2 2 4 1
Francesca Bianchi , Laura Belvederesi , Italo Bearzi , Stefano Cascinu
`
1 Clinica di Oncologia Medica, AO Ospedali Riuniti-Universita Politecnica delle Marche, Ancona, Italy, 2 Centro Regionale di Genetica Oncologica, AO Ospedali Riuniti-
` `
Universita Politecnica delle Marche, Ancona, Italy, 3 Oncologia Medica, Ospedale Profili, Fabriano, Italy, 4 Anatomia Patologica, AO Ospedali Riuniti-Universita Politecnica
`
delle Marche, Ancona, Italy, 5 Scuola di Specializzazione in Oncologia, Universita Politecnica delle Marche, Ancona, Italy
Abstract
In radically resected gastric cancer the possibility to predict the site of relapse could be clinically relevant for the selection of
post-surgical management. We previously showed that specific tumour integrins genotypes are independently associated
with either peritoneal or hematogenous metastases (ITGA and ITGV). Recently VEGF and VEGF-R polymorp
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