salksalr, a two-component signal transduction system, is essential for full virulence of highly invasive streptococcus suis serotype 2salksalr,双组分信号转导系统,对全面毒性至关重要高度侵袭性链球菌血清型2.pdfVIP

SalK/SalR, a Two-Component Signal Transduction System, Is Essential for Full Virulence of Highly Invasive Streptococcus suis Serotype 2 1,2. 2. 3,5. 2 2 2 2 Ming Li , Changjun Wang , Youjun Feng , Xiuzhen Pan , Gong Cheng , Jing Wang , Junchao Ge , 2 2 2 3 4 4 4 3 Feng Zheng , Min Cao , Yaqing Dong , Di Liu , Jufang Wang , Ying Lin , Hongli Du , George F. Gao , 4 1 1,2 Xiaoning Wang *, Fuquan Hu *, Jiaqi Tang * 1 Department of Microbiology, Third Military Medical University, Chongqing, China, 2 Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, China, 3 Center for Molecular Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, 4 Provincial Key Laboratory of Biotechnology, School of Biosciences Bioengineering, South China University of Technology, Guangzhou, China, 5 Graduate University, Chinese Academy of Sciences, Beijing, China Abstract Background: Streptococcus suis serotype 2 (S. suis 2, SS2) has evolved into a highly infectious entity, which caused the two recent large-scale outbreaks of human SS2 epidemic in China, and is characterized by a toxic shock-like syndrome. However, the molecular pathogenesis of this new emerging pathogen is still poorly understood. Methodology/Principal Findings: 89K is a newly predicted pathogenicity island (PAI) which is specific to Chinese epidemic strains isolated from these two SS2 outbreaks. Further bioinformatics analysis revealed a unique two-component signal transduction syst