sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma b16f10 cell line皮肤癌chemopreventive代理sarcophine-diol,抑制小鼠黑色素瘤b16f10细胞中增殖,促进细胞凋亡.pdfVIP

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sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma b16f10 cell line皮肤癌chemopreventive代理sarcophine-diol,抑制小鼠黑色素瘤b16f10细胞中增殖,促进细胞凋亡.pdf

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sarcophine-diol, a skin cancer chemopreventive agent, inhibits proliferation and stimulates apoptosis in mouse melanoma b16f10 cell line皮肤癌chemopreventive代理sarcophine-diol,抑制小鼠黑色素瘤b16f10细胞中增殖,促进细胞凋亡

Mar. Drugs 2012, 10, 1-19; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Sarcophine-Diol, a Skin Cancer Chemopreventive Agent, Inhibits Proliferation and Stimulates Apoptosis in Mouse Melanoma B16F10 Cell Line 1 1 2 3 Pawel T. Szymanski , Bhimanna Kuppast , Safwat A. Ahmed , Sherief Khalifa and Hesham Fahmy 1,* 1 Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA; E-Mails: pawel.szymanski@ (P.T.S.); bhimanna.kuppast@ (B.K.) 2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; E-Mail: safwat_aa@ 3 College of Pharmacy, Qatar University, Doha 02713, Qatar; E-Mail: sherief@.qa * Author to whom correspondence should be addressed; E-Mail: hesham.fahmy@; Tel.: +1-605-688-4243; Fax: +1-605-688-5993. Received: 16 November 2011; in revised form: 7 December 2011 / Accepted: 20 December 2011 / Published: 22 December 2011 Abstract: Sarcodiol (SD) is a semi-synthetic derivative of sarcophine, a marine natural product. In our previous work, we reported the significant chemopreventive effects of SD against non-melanoma skin cancer both in vitro and in vivo mouse models. In this investigation, we extended this work to study the effect of sarcodiol on melanoma development, the more deadly form of skin cancer, using the mo