原创力文档schizophrenia proteomics biomarkers on the path to laboratory medicine精神分裂症蛋白质组学实验室医学之路生物标志物.pdfVIP
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schizophrenia proteomics biomarkers on the path to laboratory medicine精神分裂症蛋白质组学实验室医学之路生物标志物
Diagnostic Pathology BioMed Central
Review Open Access
Schizophrenia proteomics: biomarkers on the path to laboratory
medicine?
Shaheen Emmanuel Lakhan*
Address: Global Neuroscience Initiative Foundation, Los Angeles, CA, USA
Email: Shaheen Emmanuel Lakhan* - slakhan@
* Corresponding author
Published: 17 July 2006 Received: 28 June 2006
Accepted: 17 July 2006
Diagnostic Pathology 2006, 1:11 doi:10.1186/1746-1596-1-11
This article is available from: /content/1/1/11
© 2006 Lakhan; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Over two million Americans are afflicted with schizophrenia, a debilitating mental health disorder
with a unique symptomatic and epidemiological profile. Genomics studies have hinted towards
candidate schizophrenia susceptibility chromosomal loci and genes. Modern proteomic tools,
particularly mass spectrometry and expression scanning, aim to identify both pathogenic-revealing
and diagnostically significant biomarkers. Only a few studies on basic proteomics have been
conducted for psychiatric disorders relative to the plethora of cancer specific experiments. One
such proteomic utility enables the discovery of proteins and biological mar
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