schistosomiasis coinfection in children influences acquired immune response against plasmodium falciparum malaria antigens血吸虫病合并感染儿童的影响获得性免疫反应对恶性疟原虫疟疾抗原.pdfVIP
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schistosomiasis coinfection in children influences acquired immune response against plasmodium falciparum malaria antigens血吸虫病合并感染儿童的影响获得性免疫反应对恶性疟原虫疟疾抗原
Schistosomiasis Coinfection in Children Influences
Acquired Immune Response against Plasmodium
falciparum Malaria Antigens
1,2 . 2,3.¤ 1,2 1,2 2
Tamsir O. Diallo * , Franck Remoue , Lobna Gaayeb , Anne-Marie Schacht , Nicole Charrier ,
2 2 2 4 2
Dick De Clerck , Jean-Pierre Dompnier , Sophie Pillet , Olivier Garraud , Abdoulaye A. N’Diaye ,
Gilles Riveau1,2
´ ´ ´ ´ ´
1 Inserm Unite 547, Institut Pasteur de Lille, Lille, France, 2 ONG ESPOIR Pour La Sante, Laboratoire de Recherches Medicales, B.P. 226, Saint-Louis, Senegal, 3 Institut de
´ ´ ˆ
Recherche pour le Developpement (IRD) - UR 016 ‘‘Caracterisation et Controle des Populations de Vecteurs’’ - BP 64501 - 34394, Montpellier, France, 4 GIMAP, EA3064,
´
Universite Jean Monnet, Saint Etienne, France
Abstract
Background: Malaria and schistosomiasis coinfection frequently occurs in tropical countries. This study evaluates the
influence of Schistosoma haematobium infection on specific antibody responses and cytokine production to recombinant
merozoite surface protein-1-19 (MSP1-19) and schizont extract of Plasmodium falciparum in malaria-infected children.
Methodology: Specific IgG1 to MSP1-19, as well as IgG1 and IgG3 to schizont extract were significantly increased in
coinfected children compared to
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