role of regulatory and proinflammatory t-cell populations in allergic diseases监管和促炎的t细胞数量在变应性疾病中的作用.pdfVIP

REVIEW ARTICLE Role of Regulatory and Proinflammatory T-Cell Populations in Allergic Diseases Kanami Orihara, PhD,* Susumu Nakae, PhD,* Þ Ruby Pawankar, MD, PhD,þ and Hirohisa Saito, MD, PhD*Þ an Bunhygienic ^ environment surrounded by many microbial Abstract: Regulatory T (Treg) cells are considered to inhibit the components is limited to early childhood.1 According to the development of both type 1 (T 1) and type 2 helper T (T 2) cells. h h classic T 1/T 2 paradigm theory, this could be typically h h However, it is recently reported that there are reduced numbers of Treg speculated as shown in Figure 1. A Th2-dominant immune cells in patients with allergic diseases as compared with individuals system develops in an individual when the immune system is who have high levels of serum immunoglobulin E and blood exposed to allergens without prior exposure to microbial eosinophils but are asymptomatic. Therefore, Treg cells may suppress components such as endotoxin early in life. On the other hand, the onset of allergic disease by down-regulating other types of immune the development of allergen (antigen)-specific Th 1 cells is cells besides T 1 and T 2 cells. The newly discovered interleukin h h