原创力文档role of runx in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupusrunx在自身免疫性疾病中的作用与类风湿性关节炎、牛皮癣和红斑狼疮.pdfVIP
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role of runx in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupusrunx在自身免疫性疾病中的作用与类风湿性关节炎、牛皮癣和红斑狼疮
Available online /content/6/4/169
Review
Role of RUNX in autoimmune diseases linking rheumatoid
arthritis, psoriasis and lupus
Marta E Alarcón-Riquelme
Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden
Corresponding author: Marta E Alarcón-Riquelme, marta.alarcon@genpat.uu.se
Received: 22 Mar 2004 Accepted: 24 May 2004 Published: 21 Jun 2004
Arthritis Res Ther 2004, 6:169-173 (DOI 10.1186/ar1203)
© 2004 BioMed Central Ltd
Abstract
Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid
arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of
autoimmune disease. A new pathway of disease pathogenesis opens new avenues of research with
thousands of questions that remain to be answered. In this review I attempt to propose how the RUNX
proteins might be involved in these diseases and review current knowledge on this very interesting trio
of transcription factors that was previously only suspected to be involved in cancer.
Keywords: autoimmunity, repression, runt-domain, susceptibility, transcription
Introduction enhancer. Importantly, the regulator element is not
The study of the genetics of complex diseases is now conserved in the mouse (ME Alarcón-Riquelme and L
advancing rapidly as new genes are being discovered that Prokunina, unpublished data), suggesting that the
are involved in susceptibility for a variety of diseases. regulation of PD-1 is different in both species. The
However, more impressive is the fact that the identification
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