role of selective v2-receptor-antagonism in septic shock a randomized, controlled, experimental study选择性在脓毒性休克v2-receptor-antagonism随机的作用,控制实验研究.pdfVIP

Rehberg et al. Critical Care 2010, 14:R200 /content/14/6/R200 RESEARCH Open Access Role of selective V -receptor-antagonism in septic 2 shock: a randomized, controlled, experimental study 1* 1 1 2 3 4 Sebastian Rehberg , Christian Ertmer , Matthias Lange , Andrea Morelli , Elbert Whorton , Martin Dünser , 1 1 1 1 5 1 Anne-Katrin Strohhäcker , Erik Lipke , Tim G Kampmeier , Hugo Van Aken , Daniel L Traber , Martin Westphal Abstract Introduction: V -receptor (V R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation 2 2 and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V R-antagonist (Propionyl -D-Tyr(Et) -Val -Abu -Arg )-Vasopressin on cardiopulmonary 2 1 2 4 6 8,9 hemodynamics and organ function vs. the mixed V R/V R-agonist arginine vasopressin (AVP) or placebo in an 1a 2 established ovine model of septic shock. Methods: After the onset of septic shock, chronically instrumented sheep were randomly assigned to receive first- line treatment with the selective V2R-antagonist (1 μg/kg per hour), AVP (0.05 μg/kg per hour), or normal saline (placebo, each n = 7). In all groups, open-label norepinephrine was additionally titrated up to 1 μg/kg per minute to maintain mean arterial pressure at