role of the transcriptional repressor bcl6 in allergic response and inflammation作用的转录阻遏bcl6过敏反应和炎症.pdfVIP

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role of the transcriptional repressor bcl6 in allergic response and inflammation作用的转录阻遏bcl6过敏反应和炎症.pdf

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role of the transcriptional repressor bcl6 in allergic response and inflammation作用的转录阻遏bcl6过敏反应和炎症

REVIEW ARTICLE Role of the Transcriptional Repressor BCL6 in Allergic Response and Inflammation Masafumi Arima, * Takeshi Fukuda,Þ and Takeshi Tokuhisa* Various allergy-related molecules are basically con- Abstract: Various molecules participate in different phases of trolled by transcriptional regulators, critical molecules allergic reactions. This means that many genes are encoding believed to govern the pathogenesis of allergic diseases by molecules related to allergic reactions, such as cytokines, chemo- regulating cytokine production, mediator synthesis, and IgE kines, and their receptors as effector molecules. The transcriptional production at gene expression levels. Recent genetic studies repressor BCL6 has emerged as a multifunctional regulator of have demonstrated that transcriptional factors and regulators lymphocyte differentiation and immune responses. BCL6-deﬁcient j/ j are involved in the development of allergic diseases. The (BCL6 ) mice display T helper type 2 (Th2)Ytype inﬂammation, molecular mechanisms of allergic diseases, in particular which is