rhodococcus bacteremia in cancer patients is mostly catheter related and associated with biofilm formation红球菌属在癌症患者大多是导管相关性菌血症和与生物膜的形成有关.pdfVIP

Rhodococcus Bacteremia in Cancer Patients Is Mostly Catheter Related and Associated with Biofilm Formation 1 1 1 1 1 Fadi Al Akhrass , Iba Al Wohoush , Anne-Marie Chaftari , Ruth Reitzel , Ying Jiang , Mahmoud 3 2 1 1 Ghannoum , Jeffrey Tarrand , Ray Hachem *, Issam Raad 1 Department of Infectious Diseases, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America, 2 Department of Microbiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America, 3 Department of Dermatology, Center for Medical Mycology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, United States of America Abstract Rhodococcus is an emerging cause of opportunistic infection in immunocompromised patients, most commonly causing cavitary pneumonia. It has rarely been reported as a cause of isolated bacteremia. However, the relationship between bacteremia and central venous catheter is unknown. Between 2002 and 2010, the characteristics and outcomes of seventeen cancer patients with Rhodococcus bacteremia and indwelling central venous catheters were evaluated. Rhodococcus bacteremias were for the most part (94%) central line-associated bloodstream infection (CLABSI). Most of the bacteremia isolates were Rhodococcus equi (82%). Rhodococcus isolates formed heavy microbial biofilm on the surface of polyurethane catheters, which was reduced completely or partially by antimicrobial lock solution. All CLABSI patients had successful response to catheter removal and antimicrobial ther