respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis an observational cohort study呼吸道症状和疾病特征预测类风湿性关节炎患者肺功能异常的一个观察性队列研究.pdfVIP

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respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis an observational cohort study呼吸道症状和疾病特征预测类风湿性关节炎患者肺功能异常的一个观察性队列研究.pdf

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respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis an observational cohort study呼吸道症状和疾病特征预测类风湿性关节炎患者肺功能异常的一个观察性队列研究

Pappas et al. Arthritis Research Therapy 2010, 12:R104 /content/12/3/R104 R E S E A R C H A R T I C L E Open Access Research article Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study Dimitrios A Pappas, Jon T Giles, Geoffrey Connors, Noah Lechtzin, Joan M Bathon and Sonye K Danoff* Abstract Introduction: Lung involvement is a common extra-articular manifestation of rheumatoid arthritis (RA) that confers significant morbidity and mortality. The objective of the present study is to assess which respiratory symptoms and patient and disease characteristics are most highly associated with pulmonary function test (PFT) abnormalities in an RA patient cohort without clinical cardiovascular disease. Methods: A total of 159 individuals with RA and without clinically evident cardiovascular disease were evaluated. Respiratory symptoms were assessed with the Lung Tissue Research Consortium questionnaire and all patients underwent evaluation with PFTs. Demographic, lifestyle, RA disease and treatment characteristics were collected. Subclinical coronary artery disease was assessed by cardiac computed tomography. Multivariable regression analysis was used to identify pulmonary symptoms and nonpulmonary parameters associated with PFT abnormalities. Areas under the receiver operating characteristic curves (AUC) were calculated to evaluate the discrimination of these variables for identifying patients with PFT abnormalities. Results: Respiratory symptoms were reported by 42% of the patient population. Although only 6% carried a prior diagnosis of lung disease, PFT abnormalities were identified in 28% of the subjects. Symptoms combined with other patient and RA characteristics (body mass index, current smoking, anti-cyclic c