role of sam chain length in enhancing the sensitivity of nanopillar modified electrodes for glucose detection山姆链长在增强nanopillar修饰电极对葡萄糖的敏感性检测.pdfVIP

Sensors 2009, 9, 1295-1305; doi:10.3390/ OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Role of SAM Chain Length in Enhancing the Sensitivity of Nanopillar Modified Electrodes for Glucose Detection Venkataramani Anandan 1, Rajan Gangadharan 1 and Guigen Zhang 1, 2, 3, 4* 1 Micro/Nano Bioengineering Lab and 2 Faculty of Engineering, The University of Georgia 3 Bioengineering, Electrical Computer Engineering, Clemson University, 4 Institute for Biological Interfaces of Engineering, Clemson University E-mails: vanandan@; rgangad@; guigen@ * Author to whom correspondence should be addressed; Bioengineering, Electrical Computer Engineering, Clemson University, 401 Rhodes Engineering Center, Clemson, SC 29634, USA Received: 27 January 2009; in revised form: 24 February 2009 / Accepted: 24 February 2009 / Published: 26 February 2009 Abstract: In this report, alkanethiol self assembled monolayers (SAM) with two different chain lengths were used to immobilize the functionalizing enzyme (glucose oxidase) onto gold nanopillar modified electrodes and the electrochemical processes of these functionalized electrodes in glucose detection were investigated. First, the formation of these SAMs on the nanopillar modified electrodes was characterized by the cyclic voltammetry and electrochemical impedance spectroscopy techniques, and then the detection sensitivity of these functionalized electrodes to glucose was evaluated