role of surgery in stages ii and iii pediatric abdominal non-hodgkin lymphoma a 5-years experience手术在第二和第三阶段小儿腹部非霍奇金淋巴瘤5年经验.pdfVIP

Cancers 2011, 3, 1593-1604; doi:10.3390/cancers3021593 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article Role of Surgery in Stages II and III Pediatric Abdominal Non-Hodgkin Lymphoma: A 5-Years Experience Amany M. Ali 1, Heba A. Sayd 1, Hesham M. Hamza 2 and Mohamed A. Salem 2,* 1 Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Asyut, Egypt; E-Mails: amanyamro@ (A.M.A.); hebadina2007@ (H.A.S.) 2 Surgical Oncology Department, South Egypt Cancer Institute, Assiut University, Asyut, Egypt; E-Mail: hesh_hamza@ * Author to whom correspondence should be addressed; E-Mail: salem641972@. Received: 26 January 2011; in revised form: 21 March 2011 / Accepted: 21 March 2011 / Published: 29 March 2011 Abstract: Abdominal Non-Hodgkin lymphomas (NHL) are the most common extra nodal presentation of pediatric NHL. Our aim is to assess the role of surgery as a risk factor and to evaluate the impact of risk-adjusted systemic chemotherapy on survival of patients with stages II and III disease. This study included 35 pediatric patients with abdominal NHL treated over five years at South Egypt Cancer Institute (SECI), Assiut University, between January 2005 and January 2010. The data of every patient included: Age, sex, and presentation, staging work up to determine extent of the disease and the type of resection performed, histopathological examination, details of chemotherapy, disease free survival and overall survival. Th