原创力文档role of testosterone in memory impairment of alzheimer disease induced by streptozotocin in male rats睾丸激素在链脲霉素引起的记忆障碍的阿尔茨海默病在雄性老鼠.pdfVIP
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role of testosterone in memory impairment of alzheimer disease induced by streptozotocin in male rats睾丸激素在链脲霉素引起的记忆障碍的阿尔茨海默病在雄性老鼠
Seyedreza et al. DARU Journal of Pharmaceutical Sciences 2012, 20:98
/content/20/1/98
REVIEW ARTICLE Open Access
Role of testosterone in memory impairment of
Alzheimer disease induced by Streptozotocin in
male rats
1 2* 1
Pourrabi Seyedreza , Mohajjel Nayebi Alireza and Hossini Seyedebrahim
Abstract
Background and purpose of the study: Recent studies demonstrate that androgens, beyond regulating sexual
behavior, exert several neuroprotective functions in the brain. The present study was designed to explore effect of
testosterone in memory impairment induced by intra- cerebroventricular (icv) injection of streptozotocin (STZ) as a
model of sporadic AD.
Methods: Study was carried out on male Wistar rats. Animals were randomly divided into 11 equal groups.
Experimental model of AD was induced by bilateral icv injection of STZ at the dose of 750 μg/Rat/10 μl ACSF at
days 1 and 3. STZ-induced memory impairment was assessed two weeks after the last dose of STZ by using a
passive avoidance task (1 mA). The interval between the placement of animals in the illuminated chamber and the
entry into the dark chamber was measured as a step-through latency (STL). Castration was performed by surgical
removing of testis and behavioral study of memory impairment was done after 4 weeks.
Results: Results of this study showed that icv injection of STZ could induce marked (p 0.05) memory impairment
at the dose of 750 μg/Rat/dissolve10 μl CSF/bilateral/days 1 and 3. Therefore, we used this dose of STZ for
induction of experimental model of AD. Memory was worsened in castrated rats (P 0.05) when compared with
normal and sham-operated animals. Testosterone replacement therapy (1 mg/kg, sc, for 6 days) in 4 week castrated
rats restored me
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