role of oxidant scavengers in the prevention of ca2+ homeostasis disorders氧化剂的拾荒者的预防ca2 +体内平衡失调.pdfVIP

Molecules 2010, 15, 7167-7187; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Role of Oxidant Scavengers in the Prevention of Ca2+ Homeostasis Disorders Carmen Galan †, Isaac Jardín †, Natalia Dionisio †, Ginés Salido and Juan A. Rosado * Cell Physiology Research Group, Department of Physiology, University of Extremadura, Caceres, 10071, Spain † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: ijp@unex.es; Tel.: +34 927257139; Fax: +34 927257110. Received: 1 July 2010; in revised form: 9 September 2010 / Accepted: 14 October 2010 / Published: 15 October 2010 Abstract: A number of disorders, such as Alzheimer disease and diabetes mellitus, have in common the alteration of the redox balance, resulting in an increase in reactive oxygen species (ROS) generation that might lead to the development of apoptosis and cell death. It has long been known that ROS can significantly alter Ca2+ mobilization, an intracellular signal that is involved in the regulation of a wide variety of cellular functions. Cells have a limited capability to counteract the effects of oxidative stress, but evidence has been provided supporting the beneficial effects of exogenous ROS scavengers. Here, we review the effects of oxidative stress on intracellular Ca2+ homeostasis and the role of antioxidants in the prevention and treatment of disorders associated to abnormal Ca2+ mobilization