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role of phospholipase a2 in retrograde transport of ricin磷脂酶a2在逆行运输的蓖麻毒素的作用
Toxins 2011, 3, 1203-1219; doi:10.3390/toxins3091203
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Article
Role of Phospholipase A2 in Retrograde Transport of Ricin
1 1 1
Tove Irene Klokk , Anne Berit Dyve Lingelem , Anne-Grethe Myrann and
Kirsten Sandvig 1,2,*
1 Centre for Cancer Biomedicine, Department of Biochemistry, Institute for Cancer Research, The
Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway;
E-Mails: tove.irene.klokk@rr-research.no (T.I.K.); anne.berit.dyve@rr-research.no (A.B.D.L.);
anne.grethe.myrann@rr-research.no (A.-G.M.)
2 Department of Molecular Biosciences, University of Oslo, 0316 Oslo, Norway
* Author to whom correspondence should be addressed; E-Mail: ksandvig@radium.uio.no;
Tel.: +47-2278-1828; Fax: +47-2278-1845.
Received: 1 July 2011; in revised form: 25 August 2011 / Accepted: 16 September 2011 /
Published: 23 September 2011
Abstract: Ricin is a protein toxin classified as a bioterror agent, for which there are no
known treatment options available after intoxication. It is composed of an enzymatically
active A-chain connected by a disulfide bond to a cell binding B-chain. After
internalization by endocytosis, ricin is transported retrogradely to the Golgi and ER, from
where the ricin A-chain is translocated to the cytosol where it inhibits protein synthesis and
thus induce
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