原创力文档science review carnitine in the treatment of valproic acid-induced toxicity – what is the evidence科学审查肉碱治疗丙戊段毒性-什么是证据.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
science review carnitine in the treatment of valproic acid-induced toxicity – what is the evidence科学审查肉碱治疗丙戊段毒性-什么是证据
Available online /content/9/5/431
Review
Science review: Carnitine in the treatment of valproic
acid-induced toxicity – what is the evidence?
Philippe ER Lheureux, Andrea Penaloza, Soheil Zahir and Mireille Gris
Department of Emergency Medicine, Acute Poisoning Unit, Erasme University Hospital, Brussels, Belgium
Corresponding author: Philippe ER Lheureux, plheureu@ulb.ac.be
Published online: 10 June 2005 Critical Care 2005, 9:431-440 (DOI 10.1186/cc3742)
This article is online at /content/9/5/431
© 2005 BioMed Central Ltd
Abstract It is usually well tolerated. Indeed, VPA has fewer common
Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is side effects than do other AEDs, especially on behaviour and
usually well tolerated, but rare serious complications may occur in cognitive functions. Moreover, its adverse effects can often
some patients receiving VPA chronically, including haemorrhagic be minimized by initiating the drug slowly. However, rare
pancreatitis, bone marrow suppression, VPA-induced hepato- serious complications may occur in some patients receiving
toxicity (VHT) and VPA-induced hyperammonaemic encephalo- VPA chronically, including fatal haemorrhagic pancreatitis,
pathy (VHE). Some data suggest that VHT and VHE may be
bone marrow suppression, VPA-induced hepatotoxicity (VHT)
promoted by carnitine deficiency. Acute VPA intoxication also
occurs as a consequence of intentional or accidental overdose and
您可能关注的文档
- role of phospholipase a2 in retrograde transport of ricin磷脂酶a2在逆行运输的蓖麻毒素的作用.pdf
- role of rho kinase in microvascular damage following cerebral ischemia reperfusion in ratsρ激酶的作用在脑缺血再灌注后大鼠微血管损害.pdf
- role of regulatory and proinflammatory t-cell populations in allergic diseases监管和促炎的t细胞数量在变应性疾病中的作用.pdf
- role of runx in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupusrunx在自身免疫性疾病中的作用与类风湿性关节炎、牛皮癣和红斑狼疮.pdf
- role of physical bolus properties as sensory inputs in the trigger of swallowing物理丸的角色属性触发器感觉输入的吞咽.pdf
- role of resistin as a marker of inflammation in systemic lupus erythematosus抵抗素的作用作为一个系统性红斑狼疮炎症状态的标志.pdf
- role of selective v2-receptor-antagonism in septic shock a randomized, controlled, experimental study选择性在脓毒性休克v2-receptor-antagonism随机的作用,控制实验研究.pdf
- role of sam chain length in enhancing the sensitivity of nanopillar modified electrodes for glucose detection山姆链长在增强nanopillar修饰电极对葡萄糖的敏感性检测.pdf
- role of surgery in stages ii and iii pediatric abdominal non-hodgkin lymphoma a 5-years experience手术在第二和第三阶段小儿腹部非霍奇金淋巴瘤5年经验.pdf
- role of survival post-progression in phase iii trials of systemic chemotherapy in advanced non-small-cell lung cancer a systematic review角色的生存post-progression iii期试验中系统性化疗在晚期非小细胞肺癌的系统评价.pdf
- science review extracellular acidosis and the immune response clinical and physiologic implications科学评估细胞外酸中毒和免疫反应的临床及生理意义.pdf
- science priorities for seamounts research links to conservation and management非常意外地研究科学重点保护和管理的链接.pdf
- science review key inflammatory and stress pathways in critical illness – the central role of the toll-like receptors科学评估关键炎症和应力路径关键疾病u2014u2014toll样受体的核心作用.pdf
- science review mechanisms of ventilator-induced injury科学审查ventilator-induced损伤机制.pdf
- science review genetic variability in the systemic inflammatory response科学评估系统性炎症反应的遗传变异性.pdf
- science review quantitative acid–base physiology using the stewart model科学评估量化酸碱生理学使用斯图尔特模型.pdf
- science review mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids科学审查机制肾上腺功能受损的败血症和分子行为的糖皮质激素.pdf
- science review recombinant human erythropoietin in critical illness a role beyond anemia科学评估重组人红细胞生成素在关键疾病除了贫血作用.pdf
- science review redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury role for hypoxia-inducible factor-1α科学评估氧化还原和oxygen-sensitive转录因子调节的低氧诱导factor-1αoxidant-mediated肺损伤的作用.pdf
- science review redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury role for nuclear factor-κb科学评估氧化还原和oxygen-sensitive调节的转录因子核factor-κb oxidant-mediated肺损伤的作用.pdf
文档评论（0）