science review extracellular acidosis and the immune response clinical and physiologic implications科学评估细胞外酸中毒和免疫反应的临床及生理意义.pdfVIP

Available online /content/8/5/331 Review Science review: Extracellular acidosis and the immune response: clinical and physiologic implications 1 2 3 John A Kellum , Mingchen Song and Jinyou Li 1Associate Professor, Critical Care Medicine and Medicine, Co-Director, The MANTRA (Mechanisms And Novel Therapies for Resuscitation and Acute illness) Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 2Research Fellow, Department of Critical Care Medicine, The MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 3Visiting Researcher, Department of Critical Care Medicine, The MANTRA Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Corresponding author: John A Kellum, kellumja@ Published online: 16 June 2004 Critical Care 2004, 8:331-336 (DOI 10.1186/cc2900) This article is online at /content/8/5/331 © 2004 BioMed Central Ltd Abstract Metabolic acidosis is among the most common abnormalities seen in patients suffering from critical illness. Its etiologies are multiple and treatment of the underlying condition is the mainstay of therapy. However, growing evidence suggests that acidosis itself has profound effects on the host, particularly in the area of immune function. Given the central importance of immune function to the outcome of critical illness, there is renewed interest in elucidating the effects of this all too common condition on the immune