science review redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury role for nuclear factor-κb科学评估氧化还原和oxygen-sensitive调节的转录因子核factor-κb oxidant-mediated肺损伤的作用.pdfVIP

Available online /content/6/6/481 Review Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-κκB John J Haddad Severinghaus-Radiometer Research Laboratories, Molecular Neuroscience Research Division, Department of Anesthesia and Perioperative Care, University of California at San Francisco, School of Medicine, San Francisco, California, USA Correspondence: John J Haddad, haddadj@ Published online: 14 October 2002 Critical Care 2002, 6:481-490 (DOI 10.1186/cc1839) This article is online at /content/6/6/481 © 2002 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract The primary role of pulmonary airways is to conduct air to the alveolar epithelium, where gas exchange can efficiently occur. Injuries to airways resulting from inhalation of airborne pollutants and parenteral exposure to ingested pollutants that cause oxidative stress have the potential to interfere with this process. A progressive rise of oxidative stress due to altered reduction–oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in lung physiology and pathophysiology. Reactive metabolites serve as signaling messengers for the evolution and perpetuation of the inflammatory process that is often associated with cell death and degeneration. Redox-sensitive transcription factors are often associated with the development and progression of many human disease states and inflammatory-related injury, particularly of the lung. The present review