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science review the brain in sepsis – culprit and victim科学评估脓毒症的大脑u2014u2014罪犯和受害者
Available online /content/9/1/37
Review
Science review: The brain in sepsis – culprit and victim
1 2 1 3
Tarek Sharshar , Nicholas S Hopkinson , David Orlikowski and Djillali Annane
1Attending Physician, Service de Réanimation Médicale, Hôpital Raymond Poincaré, Faculté de Médecine Paris Ile de France Ouest, Université de
Versailles Saint-Quentin-en-Yvelines, Garches, France
2Attending Physician, Respiratory Muscle Laboratory, Royal Brompton and Harefield NHS Trust, Fulham Road, London, SW3 6NP, United Kingdom
3Head of ICU Department, Service de Réanimation Médicale, Hôpital Raymond Poincaré, Faculté de Médecine Paris Ile de France Ouest, Université
de Versailles Saint-Quentin-en-Yvelines, Garches, France
Correspondence: Djillali Annane, djillali.annane@rpc.ap-hop-paris.fr
Published online: 8 September 2004 Critical Care 2005, 9:37-44 (DOI 10.1186/cc2951)
This article is online at /content/9/1/37
© 2004 BioMed Central Ltd
Abstract
On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side, brain
dysfunction may actively contribute to the pathogenesis of sepsis. The current review aimed at
summarizing the current knowledge about the reciprocal interaction between the immune and central
nervous systems during sepsis. The immune-brain cross talk takes part in circumventricular organs
that, being free from blood-brain-barrier, interface between brain and bloodstream, in autonomic nuclei
including the vagus nerve, and finally through the damaged e
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