science review vasopressin and the cardiovascular system part 2 – clinical physiology科学审查后叶加压素和心血管系统第2部分u2014u2014临床生理学.pdfVIP

Available online /content/8/1/15 Review Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology 1 2 3 Cheryl L Holmes , Donald W Landry and John T Granton 1Staff intensivist, Department of Medicine, Division of Critical Care, Kelowna General Hospital, Kelowna BC, Canada 2Associate Professor, Department of Medicine, Columbia University, New York, New York, USA 3Assistant Professor of Medicine, Faculty of Medicine, and Program Director, Critical Care Medicine, University of Toronto, and Consultant in Pulmonary and Critical Care Medicine, Director Pulmonary Hypertension Program, University Health Network, Toronto, Ontario, Canada Corresponding author: John T Granton, John.Granton@uhn.on.ca Published online: 26 June 2003 Critical Care 2004, 8:15-23 (DOI 10.1186/cc2338) This article is online at /content/8/1/15 © 2004 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Vasopressin is emerging as a rational therapy for vasodilatory shock states. In part 1 of the review we discussed the structure and function of the various vasopressin receptors. In part 2 we discuss vascular smooth muscle contraction pathways with an emphasis on the effects of vasopressin on ATP- sensitive K+ channels, nitric oxide pathways, and interaction with adrenergic agents. We explore the complex and contradictory studies of vasopressin on cardiac inotropy and coronary vascular tone. Finally, we summarize the clinical studies of vasopressin in shock states, which to date