science review vasopressin and the cardiovascular system part 1 – receptor physiology科学评估抗利尿激素和心血管系统的部分1 -受体的生理机能.pdfVIP

Available online /content/7/6/427 Review Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology 1 2 3 Cheryl L Holmes , Donald W Landry and John T Granton 1Staff intensivist, Department of Medicine, Division of Critical Care, Kelowna General Hospital, Kelowna BC, Canada 2Associate Professor, Department of Medicine, Columbia University, New York, New York, USA 3Assistant Professor of Medicine, Faculty of Medicine, and Program Director, Critical Care Medicine, University of Toronto, and Consultant in Pulmonary and Critical Care Medicine, Director Pulmonary Hypertension Program, University Health Network, Toronto, Ontario, Canada Corresponding author: John T Granton, John.Granton@uhn.on.ca Published online: 26 June 2003 Critical Care 2003, 7:427-434 (DOI 10.1186/cc2337) This article is online at /content/7/6/427 © 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Vasopressin is emerging as a rational therapy for vasodilatory shock states. Unlike other vasoconstrictor agents, vasopressin also has vasodilatory properties. The goal of the present review is to explore the vascular actions of vasopressin. In part 1 of the review we discuss structure, signaling pathways, and tissue distributions of the classic vasopressin receptors, namely V1 vascular, V2 renal, V3 pituitary and oxytocin receptors, and the P2 class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions of vasopressin on the vascular