原创力文档science review cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance科学审查细胞膜表达(连接)调节中性粒细胞交付,功能和间隙.pdfVIP
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science review cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance科学审查细胞膜表达(连接)调节中性粒细胞交付,功能和间隙
Available online /content/7/4/291
Review
Science review: Cell membrane expression (connectivity)
regulates neutrophil delivery, function and clearance
1 2 3
Andrew JE Seely , José L Pascual and Nicolas V Christou
1Resident, Divisions of Thoracic Surgery and Critical Care Medicine, University of Ottawa, Ottawa, Ontario, Canada
2Resident, Division of General Surgery, McGill University Health Center, Montreal, Quebec, Canada
3Professor and Chief, Division of General Surgery, McGill University Health Center, Montreal, Quebec, Canada
Correspondence: Andrew JE Seely, andrew.seely@sympatico.ca
Published online: 9 January 2003 Critical Care 2003, 7:291-307 (DOI 10.1186/cc1853)
This article is online at /content/7/4/291
© 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X)
Abstract
As the principal cellular component of the inflammatory host defense and contributor to host injury after
severe physiologic insult, the neutrophil is inherently coupled to patient outcome in both health and
disease. Extensive research has focused on the mechanisms that regulate neutrophil delivery, function,
and clearance from the inflammatory microenvironment. The neutrophil cell membrane mediates the
interaction of the neutrophil with the extracellular environment; it expresses a complex array of
adhesion molecules and receptors for various ligands, including mediators, cytokines,
immunoglobulins, and membrane molecules on other cells. This article presents a review and analysis
of
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