science review genetic variability in the systemic inflammatory response科学评估系统性炎症反应的遗传变异性.pdfVIP

Critical Care August 2003 Vol 7 No 4 Waterer and Wunderink Review Science review: Genetic variability in the systemic inflammatory response Grant W Waterer1 and Richard G Wunderink2 1Senior Lecturer in Medicine, Department of Medicine, University of Western Australia, Australia 2Director, Research Department, Methodist Le Bonheur Healthcare, Memphis and Clinical Associate Professor, University of Tennessee, Memphis, Tennessee, USA Correspondence: Richard G Wunderink, wunderir@ Published online: 4 April 2003 Critical Care 2003, 7:308-314 (DOI 10.1186/cc2164) This article is online at /content/7/4/308 © 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-α, and IL-1 receptor antagonist polymorphisms. However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule