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seasonal modification of the association between temperature and adult emergency department visits for asthma a case-crossover study季节性修改温度之间的关系和成人哮喘case-crossover研究急诊
Buckley and Richardson Environmental Health 2012, 11:55
/content/11/1/55
RESEARCH Open Access
Seasonal modification of the association between
temperature and adult emergency department
visits for asthma: a case-crossover study
*
Jessie P Buckley and David B Richardson
Abstract
Background: The objective of this study is to characterize the effect of temperature on emergency department
visits for asthma and modification of this association by season. This association is of interest in its own right, and
also important to understand because temperature may be an important confounder in analyses of associations
between other environmental exposures and asthma. For example, the case-crossover study design is commonly
used to investigate associations between air pollution and respiratory outcomes, such as asthma. This approach
controls for confounding by month and season by design, and permits adjustment for potential confounding by
temperature through regression modeling. However, such models may fail to adequately control for confounding if
temperature effects are seasonal, since case-crossover analyses rarely account for interactions between matching
factors (such as calendar month) and temperature.
Methods: We conducted a case-crossover study to determine whether the association between temperature and
emergency department visits for asthma varies by season or month. Asthma emergency department visits among
North Carolina adults during 2007–2008 were identified using a statewide surveillance system. Marginal as well as
season- and month-specific associations between asthma visits and temperature were estimated with conditional
logistic regression.
Results: The association between temperature and adult emergency department visits for asthma is near null when
the overall associat
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