selection of peptides targeting helix 31 of bacterial 16s ribosomal rna by screening m13 phage-display libraries选择针对螺旋肽31筛选细菌16 s rrna的m13噬菌体展示库.pdfVIP

下载本文档

0
0
约10.18万字
约 29页
2017-09-11 发布于上海
举报
版权申诉

selection of peptides targeting helix 31 of bacterial 16s ribosomal rna by screening m13 phage-display libraries选择针对螺旋肽31筛选细菌16 s rrna的m13噬菌体展示库.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

selection of peptides targeting helix 31 of bacterial 16s ribosomal rna by screening m13 phage-display libraries选择针对螺旋肽31筛选细菌16 s rrna的m13噬菌体展示库

Molecules 2011, 16, 1211-1239; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Selection of Peptides Targeting Helix 31 of Bacterial 16S Ribosomal RNA by Screening M13 Phage-Display Libraries Tek N. Lamichhane 1,2,‡,†, N. Dinuka Abeydeera 1,§,†, Anne-Cécile E. Duc 1,||, Philip R. Cunningham 2 and Christine S. Chow 1,* 1 Department of Chemistry, Wayne State University, Detroit, MI 48202, USA 2 Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA ‡ Current address: Intramural Research Program, NICHD, NIH, Bethesda, MD 20892, USA § Current address: Department of Chemistry, Texas AM University, College Station, TX 77843, USA || Current address: Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: csc@; Tel: +1-313-577-2594; Fax: +1-313-577-8822. Received: 5 January 2011; in revised form : 24 January 2011 / Accepted: 25 January 2011 / Published: 28 January 2011 Abstract: Ribosomal RNA is the catalytic portion of ribosomes, and undergoes a variety of conformational changes during translation. Structural changes in ribosomal RNA can be facilitated by the presence of modified nucleotides. Helix 31 of bacterial 16S ribosomal 2 5 RNA harbors two modified nucleotides, m G966 and m C967, that are highly conserved