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selenium in oncology from chemistry to clinics硒的肿瘤化学诊所
Molecules 2009, 14, 3975-3988; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Review
Selenium in Oncology: From Chemistry to Clinics †
Oliver Micke 1,*, Lutz Schomburg 2, Jens Buentzel 3, Klaus Kisters 4 and Ralph Muecke 5
1 Department of Radiotherapy and Radiation Oncology, Franziskus Hospital, Kiskerstraße 26, D-
33615 Bielefeld, Germany
2 Institute for Experimental Endocrinology, Charité Berlin, Germany;
E-Mail: lutz.schomburg@charite.de (L.S.)
3 Department of Otolaryngology, Südharz Hospital Nordhausen, Germany;
E-Mail: jens.buentzel@shk-ndh.de (J.B.)
4 Department of Internal Medicine, St. Anna Hospital, Herne, Germany;
E-Mail: kisters@annahospital.de (K.K.)
5 Department of Radiotherapy, Lippe Hospital Lemgo, Germany;
E-Mail: Ralph.Muecke@klinikum-lippe.de (R.M.)
† On behalf of the German Working Group Trace Elements and Electrolytes in Oncology (AKTE).
* Author to whom correspondence should be addressed; E-Mail: strahlenklinik@web.de;
Tel.: +49 521 5891801; Fax: + 49 521 5891804.
Received: 11 August 2009; in revised form: 26 September 2009 / Accepted: 30 September 2009 /
Published: 12 October 2009
Abstract: The essential trace element selenium, which is a crucial cofactor in the most
important endogenous antioxidative systems of the human body, is attracting more and
more the attention of both laypersons and expert groups. The interest of oncologists mainly
focuses in the following clinical aspects: radioprotection of normal tissues, radiosensitizing
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