原创力文档single-beat noninvasive imaging of ventricular endocardial and epicardial activation in patients undergoing crtsingle-beat无创性成像的心室心内膜和心外膜激活病人接受crt.pdfVIP
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single-beat noninvasive imaging of ventricular endocardial and epicardial activation in patients undergoing crtsingle-beat无创性成像的心室心内膜和心外膜激活病人接受crt
Single-Beat Noninvasive Imaging of Ventricular
Endocardial and Epicardial Activation in Patients
Undergoing CRT
1 2 2 1 2
Thomas Berger *, Bernhard Pfeifer , Friedrich F. Hanser , Florian Hintringer , Gerald Fischer , Michael
2 3 1 1 2
Netzer , Thomas Trieb , Markus Stuehlinger , Wolfgang Dichtl , Christian Baumgartner , Otmar
Pachinger1, Michael Seger2
1 Division of Cardiology, Department of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria, 2 Institute of Electrical, Electronic and Bioengineering,
University for Health Sciences, Medical Informatics and Technology (UMIT), Hall in Tirol, Austria, 3 Department of Radiology I, Medical University Innsbruck, Innsbruck,
Austria
Abstract
Background: Little is known about the effect of cardiac resynchronization therapy (CRT) on endo- and epicardial ventricular
activation. Noninvasive imaging of cardiac electrophysiology (NICE) is a novel imaging tool for visualization of both epi- and
endocardial ventricular electrical activation.
Methodology/Principal Findings: NICE was performed in ten patients with congestive heart failure (CHF) undergoing CRT
and in ten patients without structural heart disease (control group). NICE is a fusion of data from high-resolution ECG
mapping with a model of the patient’s individual cardiothoracic anatomy created from magnetic resonance imaging. Beat-
to-beat endocardial and epicardial ventricular activation sequences were computed during native rhythm as well as during
ventricular pacing using a bidomain theory-based heart model to solve the related inverse problem. During right ventricular
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