sizing the lung of mechanically ventilated patients分级机械通气病人的肺.pdfVIP

Mattingley et al. Critical Care 2011, 15:R60 /content/15/1/R60 RESEARCH Open Access Sizing the lung of mechanically ventilated patients 1† 2† 1 2 2 1* Jennifer S Mattingley , Steven R Holets , Richard A Oeckler , Randolph W Stroetz , Curtis F Buck , Rolf D Hubmayr Abstract Introduction: This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more ‘physiologic’ than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as the thoracic gas volume at an airway pressure of 40 cm H2O and tested if TLC could be inferred from the volume of gas that enters the lungs during a brief ‘recruitment’ maneuver. Methods: Lung volume at relaxed end expiration (Vrel) as well as inspiratory capacity (IC), defined as the volume of gas that enters the lung during a 5 second inflation to 40 cm H2O, were measured in 14 patients with respiratory failure. TLC was defined as the sum of IC and Vrel. The dependence of IC and Vrel on body mass index (BMI), respiratory system elastance and plateau airway pressure was assessed. Results: TLC was reduced to 59 ± 23% of that predicted. Vrel/TLC, which averaged 0.45 ± 0.11, was no different than the 0.47 ± 0.04 predicted during health in the supine posture. The greater than expected variability in observed Vrel/TLC was largely accounted for by BMI. Vrel and IC were correlated (r = 0.76). Taking BMI into account strengthened the correlation (r = 0.92). Conclusions: We conclude that body mass is a powerful determinant of lung volume and plateau airway pressure. Effective lung size ca