soluble tumor necrosis factor receptor mediates cell proliferation on lipopolysaccharide-stimulated cultured human decidual stromal cells可溶性肿瘤坏死因子受体介导细胞增殖在lipopolysaccharide-stimulated人类蜕膜基质细胞培养.pdfVIP

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soluble tumor necrosis factor receptor mediates cell proliferation on lipopolysaccharide-stimulated cultured human decidual stromal cells可溶性肿瘤坏死因子受体介导细胞增殖在lipopolysaccharide-stimulated人类蜕膜基质细胞培养.pdf

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soluble tumor necrosis factor receptor mediates cell proliferation on lipopolysaccharide-stimulated cultured human decidual stromal cells可溶性肿瘤坏死因子受体介导细胞增殖在lipopolysaccharide-stimulated人类蜕膜基质细胞培养

Int. J. Mol. Sci. 2009, 10, 2010-2018; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Soluble Tumor Necrosis Factor Receptor Mediates Cell Proliferation on Lipopolysaccharide-Stimulated Cultured Human Decidual Stromal Cells Xue-Wen Yu 1, Xin-Wen Zhang 1 and Xu Li 2,* 1 Center of Maternal and Child Health, First Affiliated Hospital of Medical School in Xi’an Jiaotong University, Xi’an, 710061, P. R. China; E-Mails: yuxuewen@ (X.-W.Y.); xianxinwen@163.com (X.-W.Z.) 2 Center of Molecular Biological Medicine, First Affiliated Hospital of Medical School in Xi’an Jiaotong University, Xi’an, 710061, P. R. China * Author to whom correspondence should be addressed; E-Mail: lixu56@ Received: 1 April 2009; in revised form: 20 April 2009 / Accepted: 27 April 2009 / Published: 4 May 2009 Abstract: The tumor necrosis factor-alpha (TNF-α) cytokine receptor system modulates apoptosis in many cell types, so we have investigated the role of sTNFR1 in bacterial lipopolysaccharide (LPS)-induced cell death in cultured human decidual stromal cells, hypothesizing that sTNFR1 might play a central role in this action. In this work we characterized in vitro decidual stromal cell viability with LPS treatment and LPS and sTNFR1 co-treatment. We found that LPS treatment induced decidual stromal cell de