原创力文档spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer tlr4 receptor on maternal blood monocytes自发早产与促炎信号传感器的增加对孕产妇血液单核细胞tlr4受体.pdfVIP
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spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer tlr4 receptor on maternal blood monocytes自发早产与促炎信号传感器的增加对孕产妇血液单核细胞tlr4受体
Pawelczyk et al. BMC Pregnancy and Childbirth 2010, 10:66
/1471-2393/10/66
RESEARCH ARTICLE Open Access
Spontaneous preterm labor is associated with an
increase in the proinflammatory signal transducer
TLR4 receptor on maternal blood monocytes
1 2,3 3 3 4 2
Edyta Pawelczyk , Bogdan J Nowicki , Michael G Izban , Siddharth Pratap , Nupur A Sashti , Maureen Sanderson
, Stella Nowicki2,3*
Abstract
Background: Localized inflammation and increased expression of TLR4 receptors within the uterus has been
implicated in the pathogenesis of preterm labor. It remains unclear whether intrauterine inflammatory responses
activate the maternal peripheral circulatory system. Therefore we determined whether increased TLR4 expression is
present in the peripheral maternal white blood cells of women with spontaneous preterm labor.
Methods: This is a cross-sectional study of 41 preterm labor cases and 41 non-preterm controls. For each case and
control sample, RNA was purified from white blood cells and TLR4 mRNA pool size was evaluated by quantitative
PCR. Protein expression levels were determined by flow cytometry. Statistical evaluation using multiple linear
regressions was used to determine any significant differences between the cases and controls. The purpose was to
determine association prevalence of TLR4 levels and preterm labor.
Results: Adjusted mean TLR4 mRNA levels of 0.788 ± 0.037 (standard error) for preterm labor and 0.348 ± 0.038 for
the corresponding pregnant control women were statistically significantly different (P = 0.002). Using the lower
95% confidence interval of the mean expression level in PTL subjects (0.7) as a cutoff value for elevated TLR4
mRNA levels, 25/41 (60.9%) o
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