原创力文档spontaneous virologic suppression in hiv controllers is independent of delayed-type hypersensitivity test responsiveness自发的病毒学抑制hiv控制器独立于dth反应测试.pdfVIP
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spontaneous virologic suppression in hiv controllers is independent of delayed-type hypersensitivity test responsiveness自发的病毒学抑制hiv控制器独立于dth反应测试
Okulicz et al. AIDS Research and Therapy 2012, 9:10
/content/9/1/10
SHORT REPORT Open Access
Spontaneous virologic suppression in HIV
controllers is independent of delayed-type
hypersensitivity test responsiveness
1,2* 3 4 5 1,6
Jason F Okulicz , Greg A Grandits , Matthew J Dolan , Vincent C Marconi , Glenn Wortmann and
Michael L Landrum1,2
Abstract
Background: Delayed-type hypersensitivity (DTH) testing, an in vivo assessment of cell-mediated immunity, is a
predictor of HIV disease progression beyond CD4 cell count. We investigated whether preserved DTH
responsiveness was characteristic of HIV controllers compared to non-controllers and individuals on suppressive
HAART.
Findings: DTH testing consisted of ≥ 3 recall antigens applied approximately every 6 months. DTH responses were
classified by the number of positive skin tests: anergic (0), partial anergic (1), or non-anergic (≥ 2). HIV controllers
were compared to treatment naïve non-controllers (n = 3822) and a subgroup of non-controllers with VL 400
copies/mL on their initial HAART regimen (n = 491). The proportion of non-anergic results at first DTH testing was
similar for HIV controllers compared to non-controllers (81.9% vs. 77.6%; P = 0.22), but tended to be greater in HIV
controllers compared to the HAART subgroup (81.9% vs. 74.5%; P = 0.07). Complete anergy was observed in 14
(10.1%) HIV controllers with CD4 counts ≥ 400 cells/uL. For longitudinal testing, the average percentage of non-
anergic DTH determinations per participant was higher in HIV controllers compared to non-controllers (81.2 ±
31.9% vs. 70.7 ± 36.8%; P = 0.0002), however this difference was eliminated with stratification by CD4 count: 200-
399 (
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