straightforward synthesis of novel 1-(2′-α-o-d-glucopyranosyl ethyl) 2-arylbenzimidazoles简单的合成新颖的1 -(2u2032-α-o-d-glucopyranosyl乙)2-arylbenzimidazoles.pdfVIP

下载本文档

2
0
约 13页
2017-09-12 发布于上海
举报
版权申诉

straightforward synthesis of novel 1-(2′-α-o-d-glucopyranosyl ethyl) 2-arylbenzimidazoles简单的合成新颖的1 -(2u2032-α-o-d-glucopyranosyl乙)2-arylbenzimidazoles.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

straightforward synthesis of novel 1-(2′-α-o-d-glucopyranosyl ethyl) 2-arylbenzimidazoles简单的合成新颖的1 -(2u2032-α-o-d-glucopyranosyl乙)2-arylbenzimidazoles

Molecules 2012, 17, 9887-9899; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles Natarajan Arumugam 1,†, Aisyah Saad Abdul Rahim 1,*, Shafida Abd Hamid 2 and 3 Hasnah Osman 1 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia 2 Kulliyyah of Science, International Islamic University Malaysia (IIUM), Jalan Istana, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia 3 School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia † Current address: Department of Chemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia. * Author to whom correspondence should be addressed; E-Mail: aisyah@usm.my; Tel.: +60-4653-4094; Fax: +60-4657-0017. Received: 27 June 2012; in revised form: 27 July 2012 / Accepted: 13 August 2012 / Published: 17 August 2012 Abstract: A series of novel 1-(2′-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles has been prepared via one-pot glycosylation of ethyl-1-(2-hydroxyethyl)-2-arylbenzimidazole- 5-carboxylate derivatives. Synthesis of the 2-arylbenzimidazole aglycones from 4-fluoro-3- nitrobenzoic acid was accomplished in four high-yielding steps. The reduction and cyclocondensation steps for the aglycone synthesis proceeded efficiently under microwave irradiation to afford the appropriate benzimidazoles in excellent yields wit