原创力文档strategies to assess hypoxichif-1-active cancer cells for the development of innovative radiation therapy策略评估hypoxichif-1-active癌细胞的发展创新的放射治疗.pdfVIP
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strategies to assess hypoxichif-1-active cancer cells for the development of innovative radiation therapy策略评估hypoxichif-1-active癌细胞的发展创新的放射治疗
Cancers 2011, 3, 3610-3631; doi:10.3390/cancers3033610
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
Strategies To Assess Hypoxic/HIF-1-Active Cancer Cells for the
Development of Innovative Radiation Therapy
Chan Joo Yeom 1, Lihua Zeng 1,2, Yuxi Zhu 1,2, Masahiro Hiraoka 2 and Hiroshi Harada 1,*
1 Group of Radiation and Tumor Biology, Career-Path Promotion Unit for Young Life Scientists,
Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan;
E-Mails: cjyeom@kuhp.kyoto-u.ac.jp (C.J.Y.); lzwei1998@ (L.Z.);
zhuyuxi@kuhp.kyoto-u.ac.jp (Y.Z.)
2 Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School
of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan;
E-Mail: hiraok@kuhp.kyoto-u.ac.jp
* Author to whom correspondence should be addressed; E-Mail: hharada@kuhp.kyoto-u.ac.jp;
Tel.: +81-75-753-9301; Fax: +81-75-753-9281.
Received: 4 August 2011; in revised form: 12 August 2011 / Accepted: 9 September 2011 /
Published: 15 September 2011
Abstract: Local tumor recurrence and distant tumor metastasis frequently occur after
radiation therapy and result in the death of cancer patients. These problems are caused, at
least in part, by a tumor-specific oxygen-poor microenvironment, hypoxia. Oxygen-
deprivation is known to inhibit the chemical ionization of both intracellular macro-
molecules and water, etc., and thus reduce the cytotoxic effects of radiation. Moreover,
DNA dam
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