synthesis and anti-bacterial activities of some novel schiff bases derived from aminophenazone合成和一些新奇的希夫碱的抗菌活动来自氨基比林.pdfVIP

Molecules 2010, 15, 6850-6858; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Synthesis and Anti-Bacterial Activities of Some Novel Schiff Bases Derived from Aminophenazone Abdullah M. Asiri 1,2 and Salman A Khan 1,* 1 Chemistry Department, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia 2 The Center of Excellence for Advanced Materials, King Abdul Aziz University, Jeddah 21589, P.O. Box 80203, Saudi Arabia * Author to whom correspondence should be addressed; E-Mail: sahmad_phd@yahoo.co.in. Received: 20 July 2010; in revised form: 16 August 2010 / Accepted: 18 August 2010 / Published: 8 October 2010 Abstract: A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR, 1H-NMR, 13C-NMR, MS) and elemental analyses. The anti-bacterial activities (with MIC values) of compounds were evaluated. The anti-bacterial screening results reveal that among the six compounds screened, four compounds showed moderate to good anti- bacterial activity. Among the tested compounds, the most effective compounds against four bacterial strains, viz. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Streptococcus pyogenes, are [(2-Chlorobenzylidene)amino]-1,5-dimethyl-2-phe