原创力文档systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis系统回顾和荟萃分析的随机试验和群组研究霉酚酸酯在狼疮肾炎.pdfVIP
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systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis系统回顾和荟萃分析的随机试验和群组研究霉酚酸酯在狼疮肾炎
Available online /content/8/6/R182
Vol 8 No 6 Open Access
Research article
Systematic review and meta-analysis of randomised trials and
cohort studies of mycophenolate mofetil in lupus nephritis
R Andrew Moore and Sheena Derry
Pain Research and Nuffield Department of Anaesthetics, University of Oxford, The Churchill, Headington, Oxford OX3 7LJ, UK
Corresponding author: R Andrew Moore, andrew.moore@pru.ox.ac.uk
Received: 14 Aug 2006 Revisions requested: 19 Sep 2006 Revisions received: 23 Oct 2006 Accepted: 12 Dec 2006 Published: 12 Dec 2006
Arthritis Research Therapy 2006, 8:R182 (doi:10.1186/ar2093)
This article is online at: /content/8/6/R182
© 2006 Moore and Derry; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Mycophenolate mofetil (MMF) is an immunosuppressant drug 16]). Serious infections, leucopaenia, amenorrhoea, and hair
being used for induction and maintenance of remission of lupus loss were all significantly less frequent with MMF than with
nephritis in systemic lupus erythematosus. Evidence about its cyclophosphamide, but diarrhoea was significantly more
use was sought from full publications and abstracts of common with MMF. Ten of 18 cohort studies enrolled only
randomised trials and cohort studies by using a variety of search patients with lupus nephritis (author-defined or WHO class III to
strategies. Efficacy and adverse event outcomes were sought. V). Seven of these 10 rep
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