原创力文档systematic review of safety and tolerability of a complex micronutrient formula used in mental health系统评价的一个复杂的安全性和耐受性微量营养素配方用于精神卫生.pdfVIP
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systematic review of safety and tolerability of a complex micronutrient formula used in mental health系统评价的一个复杂的安全性和耐受性微量营养素配方用于精神卫生
Simpson et al. BMC Psychiatry 2011, 11:62
/1471-244X/11/62
RESEARCH ARTICLE Open Access
Systematic review of safety and tolerability of a
complex micronutrient formula used in mental
health
1 2 3 4 5
J Steven A Simpson , Susan G Crawford , Estelle T Goldstein , Catherine Field , Ellen Burgess and
Bonnie J Kaplan6,7*
Abstract
Background: Theoretically, consumption of complex, multinutrient formulations of vitamins and minerals should
be safe, as most preparations contain primarily the nutrients that have been in the human diet for millennia, and
at safe levels as defined by the Dietary Reference Intakes. However, the safety profile of commercial formulae may
differ from foods because of the amounts and combinations of nutrients they contain. As these complex formulae
are being studied and used clinically with increasing frequency, there is a need for direct evaluation of safety and
tolerability.
Methods: All known safety and tolerability data collected on one complex nutrient formula was compiled and
evaluated.
Results: Data were assembled from all the known published and unpublished studies for the complex formula
with the largest amount of published research in mental health. Biological safety data from 144 children and adults
were available from six sources: there were no occurrences of clinically meaningful negative outcomes/effects or
abnormal blood tests that could be attributed to toxicity. Adverse event (AE) information from 157 children and
adults was available from six studies employing the current version of this formula, and only minor, transitory
reports of headache and nausea emerged. Only one of the studies permitted a direct comparison between
micronutrient treatment a
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