原创力文档systematic reviews on behavioural and psychological symptoms in the older or demented population系统评价行为和心理症状的老年人口或精神错乱.pdfVIP
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systematic reviews on behavioural and psychological symptoms in the older or demented population系统评价行为和心理症状的老年人口或精神错乱
van der Linde et al. Alzheimer ’s Research Therapy 2012, 4:28
/content/4/4/28
RESEARCH Open Access
Systematic reviews on behavioural and
psychological symptoms in the older or
demented population
1* 1 2 3 1
Rianne M van der Linde , Blossom CM Stephan , George M Savva , Tom Dening and Carol Brayne
Abstract
Introduction: Behavioural and psychological symptoms of dementia (BPS) include depressive symptoms, anxiety,
apathy, sleep problems, irritability, psychosis, wandering, elation and agitation, and are common in the non-
demented and demented population.
Methods: We have undertaken a systematic review of reviews to give a broad overview of the prevalence, course,
biological and psychosocial associations, care and outcomes of BPS in the older or demented population, and
highlight limitations and gaps in existing research. Embase and Medline were searched for systematic reviews
using search terms for BPS, dementia and ageing.
Results: Thirty-six reviews were identified. Most investigated the prevalence or course of symptoms, while few
reviewed the effects of BPS on outcomes and care. BPS were found to occur in non-demented, cognitively
impaired and demented people, but reported estimates vary widely. Biological factors associated with BPS in
dementia include genetic factors, homocysteine levels and vascular changes. Psychosocial factors increase risk of
BPS; however, across studies and between symptoms findings are inconsistent. BPS have been associated with
burden of care, caregiver’s general health and caregiver depression scores, but findings are limited regarding
institutionalisation, quality of life and disease outcome.
Conclusions: Limitations of reviews inclu
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