tag snp polymorphism of ccl2 and its role in clinical tuberculosis in han chinese pediatric population标记snp ccl2多态性及其作用在临床结核病在汉族小儿人口.pdfVIP

Tag SNP Polymorphism of CCL2 and Its Role in Clinical Tuberculosis in Han Chinese Pediatric Population 1 2 3,4 5 1 3,4 Wei-Xing Feng , Igor Mokrousov *, Bin-Bin Wang , Hugh Nelson , Wei-Wei Jiao , Jing Wang , Lin 1 3,4 1 1 1 3,4 1 Sun , Si-Rui Zhou , Jing Xiao , Yi Gu , Xi-Rong Wu , Xu Ma , Adong Shen * 1 Beijing Pediatric Research Institute, Beijing Children’s Hospital affiliated to Capital Medical University, Beijing, China, 2 Laboratory of Molecular Microbiology, St Petersburg Pasteur Institute, St Petersburg, Russia, 3 Graduate School, Peking Union Medical College, Beijing, China, 4 National Research Institute for Family Planning, Beijing, China, 5 International SOS Clinic, Shekou, Shenzhen, China Abstract Background: Chemokine (C-C motif) ligand 2 CCL2/MCP-1 is among the key signaling molecules of innate immunity; in particular, it is involved in recruitment of mononuclear and other cells in response to infection, including tuberculosis (TB) and is essential for granuloma formation. Methodology/Principal Findings: We identified a tag SNP for the CCL2/MCP-1 gene (rs4586 C/T). In order to understand whether this SNP may serve to evaluate the contribution of the CCL2 gene to the expression of TB disease, we further analysed distribution of its alleles and genotypes in 301 TB cases versus 338 non-infected controls (all BCG vaccinated) representing a high-risk pediatric population of North China. In the male TB subgroup, the C allele was identified in a higher rate (P = 0.045), and, acting