原创力文档takayasus arteritis is associated with hla-b52, but not with hla-b51, in turkey与人巨细胞病毒hla-b52,但不是hla-b51,在土耳其.pdfVIP
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takayasus arteritis is associated with hla-b52, but not with hla-b51, in turkey与人巨细胞病毒hla-b52,但不是hla-b51,在土耳其
Sahin et al. Arthritis Research Therapy 2012, 14:R27
/content/14/1/R27
RESEARCH ARTICLE Open Access
Takayasu’s arteritis is associated with HLA-B*52,
but not with HLA-B*51, in Turkey
1 2 3 4 5 5 6
Ziver Sahin , Muge Bıcakcıgil , Kenan Aksu , Sevil Kamali , Servet Akar , Fatos Onen , Omer Karadag ,
7 7 8 1 9 10 11
Zeynep Ozbalkan , Askin Ates , Huseyin TE Ozer , Vuslat Yilmaz , Emire Seyahi , Mehmet A Ozturk , Ayse Cefle ,
Veli Cobankara 12, A Mesut Onat13, Ercan Tunc14, Nursen Düzgün15, Sibel Z Aydin16, Neslihan Yilmaz16,
9 7 6 5 4 3 1
İzzet Fresko , Yasar Karaaslan , Sedat Kiraz , Nurullah Akkoc , Murat Inanc , Gokhan Keser , F Aytul Uyar ,
16* 1
Haner Direskeneli and Güher Saruhan-Direskeneli , for the Turkish Takayasu Study Group
Abstract
Introduction: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor
amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet’s disease
and HLA-B*52 in Takayasu’s arteritis (TAK)) and with major clinical and immunological differences. In this study, we
aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as
susceptibility and severity factors.
Methods: TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of
the patients was 37.8 years, and 86% were women. DN
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