原创力文档temperature-responsive polymer modified surface for cell sheet engineering鬼屋方面聚合物改性表面细胞片工程.pdfVIP
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temperature-responsive polymer modified surface for cell sheet engineering鬼屋方面聚合物改性表面细胞片工程
Polymers 2012, 4, 1478-1498; doi:10.3390/polym4031478
OPEN ACCESS
polymers
ISSN 2073-4360
/journal/polymers
Review
Temperature-Responsive Polymer Modified Surface for Cell
Sheet Engineering
Zhonglan Tang, Yoshikatsu Akiyama and Teruo Okano *
Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’s Medical
University, 8-1 Kawada-cho, Shinjuku, Tokyo 162-8666, Japan;
E-Mails: zltang@abmes.twmu.ac.jp (Z.T.); yakiyama@abmes.twmu.ac.jp (Y.A.)
* Author to whom correspondence should be addressed; E-Mail: tokano@abmes.twmu.ac.jp;
Tel.: +81-3-3353-8111 (ext.6201); Fax: +81-3-3359-6046.
Received: 23 April 2012; in revised form: 17 July 2012 / Accepted: 30 July 2012 /
Published: 15 August 2012
Abstract: In the past two decades, as a novel approach for tissue engineering, cell sheet
engineering has been proposed by our laboratory. Poly(N-isopropylacrylamide) (PIPAAm),
which is a well-known temperature-responsive polymer, has been grafted on tissue culture
polystyrene (TCPS) surfaces through an electron beam irradiated polymerization. At 37 °C,
where the PIPAAm modified surface is hydrophobic, cells can adhere, spread on the
surface and grow to confluence. By decreasing temperature to 20 °C, since the surface
turns to hydrophilic, cells can detach themselves from the surface spontaneously and form
an intact cell sheet with extracellular matrix. For obtaining a temperature-induced cell
attachment and detachment, it is necessary to immobilize an ult
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