terpenyl-purines from the sea从海上terpenyl-purines.pdfVIP

Mar. Drugs 2009, 7, 833-849; doi:10.3390/md7040833 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Terpenyl-Purines from the Sea Marina Gordaliza Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel de Unamuno, 37007 Salamanca, Spain; E-Mail: mliza@usal.es; Tel.: +34-923-294-528; Fax: +34-923-294-515 Received: 12 November 2009; in revised form: 26 November 2009 / Accepted: 22 December 2009 / Published: 23 December 2009 Abstract: Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis , and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives. Keywords: agelasine; agelasimine; ageline; asmarine; alkyl-purine; terpene-purine; terpenylpurine 1